Dr. Abhijit Sinha Roy
Director, Imaging, Biomechanics and Mathematical Modeling Solutions
Dr. Abhijit Sinha Roy
Director, Imaging, Biomechanics and Mathematical Modeling Solutions
Narayana Nethralaya, Narayana Health city,
# 258/A, Bommasandra Hosur road,
Bangalore 560 099
Dr. Abhijit Sinha Roy completed his master's (MS) in mechanical engineering and received doctoral degree specializing in "Cardiovascular Bioengineering" from University of Cincinnati, USA. He completed post-doctoral fellowship from Cleveland Clinic Cole Eye Institute, USA and worked as senior research associate. His interests are mainly in the fields of soft tissue biomechanics and diagnostic optical imaging. He has developed novel biomechanical models for patient-specific 3-D characterization of corneal biomechanics both in response to surgery and under disease conditions. These models were the first to describe that surgery can alter the biomechanical condition of the cornea in addition to removal to tissue. His paper on the biomechanics of keratoconus and the effect of different ultraviolet beam profiles on simulated crosslinking formed the basis of cone location specific crosslinking, which is now marketed by leading USA medical device company (Avedro Inc., USA). Recently, he developed simulation based inverse finite element methods that can characterize the biomechanical properties of the cornea from in vivo measurements of topography and corneal deformation. He was also involved in the development of novel application of optical coherence tomography for corneal elastography. In subsequent studies, elastography was shown to be a sensitive quantifier of corneal biomechanical changes after crosslinking and in edematous corneas.
He has an active translational research program. Presently, he has 4 active research grants both from federal and industry sponsors. Recently, he was awarded the prestigious Indo-German Science and Technology award for a novel project on corneal biomechanics as a principal investigator. His publication record includes several papers in leading scientific journals including Investigative Ophthalmology and Vision Sciences, Journal of Refractive Surgery, Journal of Cataract and Refractive Surgery, American Journal of Ophthalmology, Ophthalmology and Journal of Biomechanics. He is presently considered as a leading authority in the field of ocular biomechanics.
Title of Invention: Whole-Eye Computational Model of the Eye, Patent No: 12/429,149, Publish Date: August 27th, 2012.
Title of Invention: Application of intraoperative tomographic image analysis for ophthalmic surgical planning, Filed by Narayana Nethralaya Foundation, 2015.
Title of Invention: Quantification of Bowman's layer for diagnosis of disease and prognosis of treatments in the human cornea, Filed by Narayana Nethralaya Foundation, 2015.
2015-2018; PI, Indo-German Science and Technology Center, Next-generation dynamic Scheimpflug imaging and biomechanical analytics for in vivo quantification of corneal viscoelasticity : This project will develop next generation Scheimpflug based air-puff technology for fast and accurate acquisition of corneal deformation characteristics.
2015-2017; PI, Carl Zeiss, Comparison of longitudinal biomechanical changes in cornea after femtosecond LASIK and SMILE : The goal of this proposal is to characterize longitudinal biomechanical changes after bilateral LASIK and SMILE with similar refraction and corneal tomography
2015-2017; PI, Bioptigen, Intra-operative keratometry using high speed intra-operative optical coherence tomography : The major goal of this project is to develop real-time in vivo corneal tomography for applications in intra-operative surgical planning.
2016-2018; PI, Abbott Medical Optics, Comparison of next generation refractive treatments: iDesign vs. SMILE : The major goal of this projects is to compare prospectively the aberrometric and optical quality of vision of patients undergoing refractive treatment on two different laser platforms.
2011-2012; Topcon, Inverse estimation of material property changes following collagen cross-linking : The goal of this project was to develop an inverse finite element algorithm to estimate stiffening of corneal tissue after collagen crosslinking
2011-2012; Carl Zeiss, Biomechanical comparison of LASIK and SMILE procedures : The goal of this project was to assess biomechanical redistribution of stress in the flap/cap region of the stroma after LASIK and SMILE using a custom ablation algorithm.
Sinha Roy A, Banerjee RK, Back LH, Back MR, Khoury SF, Millard RW. Delineating the guidewire flow obstruction effect in assessment of fractional flow reserve and coronary flow reserve measurements. American Journal of Physiology: Heart and Circulatory Physiology. 2005; 289: H392-H397.
Park J, Bungay PM, Lutz RJ, Augsburger JJ, Millard RW, Sinha Roy A, Banerjee RK. Evaluation of coupled convective-diffusive transport of drugs administered by intravitreal injection and controlled release implant. Journal of Controlled Release. 2005; 105: 279–295.
Sinha Roy A, Back LH, Banerjee RK. Guidewire flow obstruction effect on pressure drop-flow relationship in moderate coronary artery stenosis. Journal of Biomechanics. 2006; 39: 853-864.
Banerjee RK, Sinha Roy A, Back LH, Back MR, Khoury SF, Millard RW. Characterizing momentum change and viscous loss of a hemodynamic endpoint in assessment of coronary lesions. Journal of Biomechanics. 2007; 40(3): 652-62.
Sinha Roy A, Rontala RS, West K, Greenberg RK, Banerjee RK. In vitro measurement and calculation of drag force on iliac limb stentgraft in a compliant artery wall model. Molecular and Cellular Biomechanics. 2008; 4(4): 211-226.
Sinha Roy A, Back MR, Khoury SF, Schneeberger EW, Back LH, Velury VV, Millard RW, Banerjee RK. Functional and anatomical diagnosis of coronary artery stenoses. Journal of Surgical Research. 2008; 150: 24-33.
Krishnamoorthy M, Roy-Chaudhury P, Wang Y, Sinha Roy A, Zhang J, Khoury S, Munda R, Banerjee RK. Measurement of hemodynamic and anatomic parameters in a swine arteriovenous fistula model: a technical note with possibilities for the future. Journal of Vascular Access. 2008; 9(1): 28-34.
Krishnamoorthy MK, Banerjee RK, Wang Y, Zhang J, Sinha Roy A, Khoury SF, Arend LJ, Rudich S, Roy-Chaudhury P.
Hemodynamic wall shear stress profiles influence the magnitude and pattern of stenosis in a pig AV fistula. Kidney International. 2008; 74(11): 1410-9.
Sinha Roy A, Back LH, Banerjee RK. Evaluation of compliance of arterial vessel using coupled fluid structure interaction analysis. Molecular and Cellular Biomechanics. 2008; 5(4): 229-246.
Sinha Roy A, Dupps WJ, Jr. Effects of altered corneal stiffness on native and post-LASIK corneal biomechanical behavior: A whole-eye finite element analysis. Journal of Refractive Surgery. 2009; 25(10): 875-87.
Thornton IL, Dupps WJ, Jr., Sinha Roy A, Krueger RR. Biomechanical effects of intraocular pressure elevation on optic nerve/lamina cribrosa before and after peripapillary scleral collagen crosslinking. Investigative Ophthalmology and Visual Science. 2009; 50(3): 1227-33.
Banerjee RK, Ashtekar KD, Effat MA, Helmy TA, Kim E, Schneeberger EW, Sinha Roy A, Gottliebson WM, Back LH. Concurrent assessment of epicardial coronary artery stenosis and microvascular dysfunction using diagnostic endpoints derived from fundamental fluid dynamics principles. Journal of Invasive Cardiology. 2009; 21(10): 511-17.
de Medeiros FW, Sinha Roy A, Alves MR, Wilson SE, Dupps WJ. Differences in the early biomechanical effects of hyperopic and myopic LASIK. Journal of Cataract and Refractive Surgery. 2009; 36(6): 947-53.
Sinha Roy A., Dupps WJ. Patient-Specific modeling of corneal refractive surgery outcomes and inverse estimation of elastic property changes. ASME Journal of Biomechanical Engineering, 2011; 133: 011002-1-10.
Ford MR, Dupps WJ Jr., Rollins AM, Sinha Roy A, Hu Zhilin. A method for optical coherence elastography of the cornea.Journal of Biomedical Optics. 2011; 16(1): 016005.
Ruberti JW, Sinha Roy A, Roberts CJ. Corneal biomechanics and biomaterials. Annual Review of Biomedical Engineering. 2011; 13: 269-95.
Medeiros FW, Sinha Roy A, Alves MR, Dupps WJ Jr. Biomechanical corneal changes induced by different flap thickness created by femtosecond laser. Clinics. 2011; 66(6): 1067-71.
Salomão MQ, Chaurasia SS, Sinha Roy A, Ambrósio R, Jr., Esposito A, Sepulveda R, Agrawal V, Wilson SE. Corneal wound healing after riboflavin- UV-A collagen crosslinking- a rabbit study. Journal of Refractive Surgery. 2011; 27(6): 401-7.
Ambrósio R, Jr, Caiado ALC, Guerra FP, Louzada R, Sinha Roy A, Luz A, Dupps WJ, Belin MW. Novel pachymetric parameters based on corneal tomography for diagnosing Keratoconus. Journal of Refractive Surgery. 2011; 27(10):753-758.
Sinha Roy A, Dupps WJ. Patient-Specific Computational Modeling of Keratoconus Progression and Differential Responses to Collagen Crosslinking. Investigative Ophthalmology and Visual Science. 2011; 52(12):9174-87.
Hong CW, Sinha Roy A, Schoenfiled L, McMahon JT, Dupps WJ. Collagenase-mediated tissue modeling of corneal ectasia and collagen cross-linking treatments. Investigative Ophthalmology and Visual Science. 2012; 53(4):2321-7.
Armstrong BK, Lin MP, Ford MR, Santhiago MR, Singh V, Grossman GH, Agrawal V, Sinha Roy A, Butler RS, Dupps WJ, Wilson SE. Biological and biomechanical responses to traditional epithelium-Off and transepithelial riboflavin-UVA crosslinking techniques in rabbits. Journal of Refractive Surgery. 2013; 29(5): 332-41.
Sinha Roy A, Rocha KM, Randleman JB, Stulting RD, Dupps WJ Jr. Inverse computational analysis of in vivo corneal elastic modulus change after collagen crosslinking for keratoconus. Experimental Eye Research. 2013; 113:92-104.
Sinha Roy A, Shetty R, Kummelil MK. Keratoconus: a biomechanical perspective on loss of corneal stiffness. Indian J Ophthalmol. 2013; 61(8):392-3.
Hallahan KM, Sinha Roy A, Ambrosio R Jr, Salomao M, Dupps WJ Jr. Discriminant value of custom ocular response analyzer waveform derivatives in keratoconus. Ophthalmology. 2014; 121(2): 459-68.
Battu R, Dabir S, Khanna A, Kumar AK, Sinha Roy A. Adaptive optics imaging of the retina. Indian J Ophthalmol. 2014 ; 62(1): 60-5.
Seven I, Sinha Roy A, Dupps WJ. Patterned corneal collagen crosslinking for astigmatism: Computational modeling study. Journal of Cataract and Refractive Surgery. 2014: 40: 943-953.
Ford MR, Sinha Roy A, Rollins AM, Dupps WJ. Serial biomechanical comparison of edematous, normal, and collagen crosslinked human donor corneas using optical coherence elastography. Journal of Cataract and Refractive Surgery. 2014; 40: 1041-1047.
Sinha Roy A, Dupps WJ, Roberts CJ. Comparison of biomechanical effects of small incision lenticule extraction (SMILE) and laser in situ keratomileusis (LASIK): a finite element analysis study. Journal of Cataract and Refractive Surgery. 2014; 40: 971-980.
Santhiago MR, Wilson SE, Hallahan KM, Smadja D, Lin M, Ambrosio R Jr, Singh V, Sinha Roy A, Dupps WJ Jr. Changes in custom biomechanical variables after femtosecond laser in situ keratomileusis and photorefractive keratectomy for myopia. Journal of Cataract and Refractive Surgery. 2014: 40: 918-928.
Tejwani S, Shetty R, Kurien M, Dinakaran S, Ghosh A, Sinha Roy A. Biomechanics of the Cornea Evaluated by Spectral Analysis of Waveforms from Ocular Response Analyzer and Corvis-ST. PLoS One. 2014; 9(8): e97591.
Hallahan KM, Rocha K, Sinha Roy A, Randleman JB, Stulting RD, Dupps WJ Jr. Effects of corneal cross-linking on ocular response analyzer waveform-derived variables in keratoconus and postrefractive surgery ectasia. Eye Contact Lens. 2014; 40(6): 339-44.
Shetty R, Nuijts R, Nicholson M, Sargod K, Jayadev C, Veluri H, Sinha Roy A. Cone location dependent outcomes after combined topography-guided photorefractive keratectomy and collagen crosslinking. American Journal of Ophthalmology. 2015; 159(3): 419-25.
Dabir S, Mangalesh S, Kumar KA, Kummelil MK, Sinha Roy A, Shetty R. Variations in the cone packing density with eccentricity in emmetropes. Eye. 2014; 28(12): 1488-93.
Shetty R, Ghosh A, Lim RR, Subramani M, Mihir K, Reshma AR, Shetty R, Ranganath A, Nagaraj S, Nuijts RMMA, Bueurman R, Das D, Chaurasia SS, Sinha Roy A, Ghosh A. Elevated expression of Matrix Metalloproteinase 9 and Inflammatory Cytokines in Keratoconus Patients is inhibited by Cyclosporine A. Investigative Ophthalmology and Visual Science. 2015; 56(2): 738-50.
Shetty R, Sathyanarayanamoorthy A, Ramachandra RA, Arora V, Ghosh A, Srivatsa P, Pahuja N, Nuijts RMMA, Sinha Roy A, Ghosh A. Attenuation of lysyl oxidase and collagen gene expression in keratoconus patient corneal epithelium corresponds to disease severity. Molecular Vision. 2015; 21: 12-25.
Shetty R, Kawer L, Pahuja N, Deshpande K, Thakkar M, Sinha Roy A. Association between corneal deformation and ease of lenticule separation from residual stroma in small incision lenticule extraction. Cornea. 2015; 34: 1067-71.
Sinha Roy A, Kurian M, Matalia H, Shetty R. Air-puff associated quantification of non-linear biomechanical properties of the human cornea in vivo. Journal of Mechanical Behavior of Biomedical Materials. 2015; 48: 173-82.
Shetty R, Matalia H, Srivatsa P, Ghosh A, Dupps WJ Jr, Sinha Roy A. A novel Zernike application to differentiate between three-dimensional corneal thickness of normal corneas and corneas with keratoconus. American Journal of Ophthalmology. 2015; 160: 453-462.
Shetty R, Nuijts RM, Srivatsa P, Jayadev C, Pahuja N, Akkali MC, Sinha Roy A. Understanding the Correlation between Tomographic and Biomechanical Severity of Keratoconic Corneas. Biomedical Research International. 2015:294197.
Beene L, Traboulsi E, Seven I, Ford M, Sinha Roy A, Butler R, Dupps WJ Jr. Corneal deformation response and ocular geometry: a non-invasive diagnostic strategy in Marfan syndrome. American Journal of Ophthalmology. 2016; 161: 56-64.
Tejwani S, Dinakaran S, Joshi A, Shetty R, Sinha Roy A. A cross-sectional study to compare intraocular pressure measurement by sequential use of Goldman applanation tonometry, dynamic contour tonometry, ocular response analyzer, and Corvis ST. Indian Journal of Ophthalmology. 2015; 63(11): 815-20.
Gadde SG, Anegondi N, Bhanushali D, Chidambara L, Yadav NK, Khurana A, Sinha Roy A. Quantification of Vessel Density in Retinal Optical Coherence Tomography Angiography Images Using Local Fractal Dimension. Investigative Ophthalmology and Vision Science. 2016; 57(1): 246-52.
Tejwani S, Devi S, Dinakaran S, Shetty R, Meshram P, Francis M, Sinha Roy A. Diagnostic Efficacy of Normalization of Corneal Deformation Variables by the Intraocular Pressure in Glaucomatous Eyes. Investigative Ophthalmology and Vision Science. 2016; 57(3): 1082-1086.
Shetty R, Shroff R, Kaweri L, Jayadev C, Kummelil MK, Sinha Roy A. Intra-Operative Cap Repositioning in Small Incision Lenticule Extraction (SMILE) for Enhanced Visual Recovery. Current Eye Research. 2016; 1-7.
Pahuja N, Kumar NR, Francis M, Shanbagh S, Shetty R, Ghosh A, Sinha Roy A. Correlation of Clinical and Biomechanical Outcomes of Accelerated Crosslinking (9 mW/cm2 in 10 minutes) in Keratoconus with Molecular Expression of Ectasia-Related Genes. Current Eye Research. 2016; 1-5.
Bhanushali D, Anegondi N, Gadde SGK, Srinivasan P, Chidamabara L, Yadav NK, Sinha Roy A. Special Issue on OCT: Linking retinal microvasculature features with severity of diabetic retinopathy using Optical Coherence tomography angiography. Investigative Ophthalmology and Vision Science. 2016; 57(9): OCT519-25.
Matalia J, Francis M, Tejwani S, Dudeja G, Rajappa N, Sinha Roy A. Role of Age and Myopia in Simultaneous Assessment of Corneal and Extraocular Tissue Stiffness by Air-Puff Applanation. Journal of Refractive Surgery. 2016; 57(3): 1082-6.
Pahuja N, Shroff R, Pahanpate P, Francis M, Veeboy L, Shetty R, Nuijts RM, Sinha Roy A. Application of high resolution OCT to evaluate irregularity of Bowman's layer in asymmetric keratoconus. Journal of Biophotonics. 2016; doi: 10.1002/jbio.201600106.
Kumar, R. S., N. Anegondi, R. S. Chandapura, S. Sudhakaran, S. V. Kadambi, H. L. Rao, T. Aung and A. Sinha Roy. Discriminant Function of Optical Coherence Tomography Angiography to Determine Disease Severity in Glaucoma. Investigative ophthalmology & visual science 2016;57:6079-88
Matalia H, Francis M, Gangil T, Chandapura R, Kurian M, Shetty R, Nelson E, Sinha Roy. Non-contact quantification of topography of anterior corneal surface and Bowman's layer with high speed OCT. Journal of Refractive Surgery. 2017; In press.