3rd Floor, Narayana Nethralaya, Narayana Health City
# 258/A, Bommasandra, Hosur Road,
Bengaluru, 560099 INDIA.
Trailokyanath Panigrahi, Research Associate at GROW research laboratory.
MSc (Applied microbiology) from Vellore Institute of Technology, India.
BSc (Chemistry, Genetics, Biotechnology) from The Oxford College of Sciences, Bangalore University, India
Dry eye disorder (DED) is a multifactorial condition affecting millions worldwide. It is characterized by reduced tear fluid volume, altered tear fluid dynamics, hyperosmolarity, ocular surface inflammation and pain/discomfort. The conditions reduces the quality of life and result in depression. Numerous topical medications ranging from artificial tear substitutes to anti-inflammatory agents are available. However, a substantial subset of patients are refractory to currently treatment options. Hence, there is a continuous search for additional strategies to mitigate the causal mechanisms underlying DED. Channel proteins play a major role maintaining the ionic balance on ocular surface, any functional defect in these leads to ionic imbalance and disrupts cellular homeostasis. Cystic fibrosis transmembrane conductance regulator (CFTR), a selective chloride-ion channel regulator, is among one of them and is expressed on ocular surface cells. Patients carrying a defective CFTR channel often present with dry eye like signs and symptoms. Hence, we are currently engaged in finding the mechanism on how CFTR defect leads to DED and find drugs to modulate CFTR to resolve DED signs and symptoms. We are also involved in mass spectrometry based proteomic analysis for identification of biomarkers in various ocular diseases.
1. Shivapriya Shivakumar, Trailokyanath Panigrahi, Rohit Shetty, Murali Subramani, Arkasubhra Ghosh, and Nallathambi Jeyabalan, “Chloroquine Protects Human
Corneal Epithelial Cells from Desiccation Stress Induced Inflammation without Altering the Autophagy Flux,” BioMed Research International, 2018, 2018. https://doi.org/10.1155/2018/7627329.
2. Martin LM., Jeyabalan N., Tripathi R., Panigrahi T., Johnson PJ., Ghosh A., Mohan RR. “Autophagy in corneal health and disease: A concise review,” Ocul Surf. 2019 Apr;17(2):186-197. DOI:10.1016/j.jtos.2019.01.008.
3. Trailokyanath Panigrahi, Shivapriya Shivakumar, Rohit Shetty, Sharon D'souza, Everette Jacob Remington Nelson, Swaminathan Sethu, Nallathambi Jeyabalan,
and Arkasubhra Ghosh. "Trehalose augments autophagy to mitigate stress induced inflammation in human corneal cells,.." The ocular surface 17.4 (2019): 699-713.