Keratoconus (KC) is a corneal ectatic disease characterized by progressive focal thinning and irregular astigmatism that leads to reduced visual acuity. Our research focuses on unravelling the mechanisms underlying KC
Autophagy (self-eating process) is an essential cellular mechanism that is important for variety of normal development and physiological conditions. It is fundamental cellular machinery which controls intracellular protein trafficking and degradation pathways and protect against aging, cancer, neurodegenerative disorders, inflammatory, and metabolic diseases, including infections. The current research focus is to identify the role of autophagic lysosomal pathway in ophthalmic disorders using various biochemical and genetic approaches, to elucidate the molecular mechanism of normal and disease progression, prevention.