Aplastic Anemia is an autoimmune disorder damaging the bone marrow’s ability to produce hematopoietic stem cells leading to pancytopenia (loss of all three types of blood cells – Erythrocytes, Leukocytes and Thrombocytes). Our lab is currently working on understanding the mechanisms involved in deregulation of the telomerase (TERT) enzyme in AA patients.
Craniosynostosis is a sporadic skull deformity, affecting 1 in 2500 live births. This is caused due to premature fusion of one or more cranial vault sutures due to aberrant cellular signaling events that regulates growth and differentiation at the suture margins. Our research focuses on the regulation of bone formation to understand the mechanisms underlying the craniofacial defects
Atherosclerosis is a disease of arteries where there is a thickening of arterial wall due to fibrosis . Atherosclerosis leads to stenosis thereby leading to reduced blood flow to the organs in the affected area. Atherosclerotic plaques are complex in nature with multiple cell types involved in its pathogenesis and progression. They are localized in nature and thus we study the gene expression differences in diseased and non-diseased tissue from the same patients.