Retinoblastoma is a unique cancer that forms in the eyes of children. It is a complicated disease predisposed primarily by genetic mutations in RB1 in one or more cells of the retina. It may be triggered by the loss of function or mechanistic alterations of other genes by various chromosomal or mutational events. Retinoblastoma arises when genetic changes in the precursor cell initiate tumor formation inside the retina. The incidence of retinoblastoma is 1 in 20,000 live births, with about estimated 2000 children being diagnosed in India each year. It is the most common intraocular cancer in India.
Histopathology of Retinoblastoma
Integrated biology approach to study retinoblastoma
3D Cell culture: Hanging Drop
Glioblastoma, WHO Grade IV, is characterized by its highly invasive nature and poor prognosis. Our research is primarily focused on understanding the invasion mechanism using Oligodendrocyte Precursor Cell (OPC) derived glioma model. This work is carried out in collaboration with Dr. Martin Sailer at University of Basel, Switzerland
Invasion model of Glioblastoma
Head and Neck cancer
Being the most prevalent form of cancer in adults in the subcontinent, it is important to understand the mechanisms of chemoresistance and recurrence. Our laboratory attempts to understand these processes by discovery and validation experiments in primary tumor samples and through investigations in disease models in culture. The studies are done in collaboration with Prof. Kuriakose and Dr. Suresh at MSCTR.