Publications

Dhamodaran K, Subramani M, Krishna L, Matalia H, Jayadev C, Chinnappaiah N, Shetty R, Das D. Temporal regulation of Notch signaling and its influence on the differentiation of ex vivo cultured limbal epithelial cells. Current Eye Research. 2019 Sep 29. PMID: 31558050


Panigrahi T, Shivakumar S, Shetty R, D'souza S, Nelson EJ, Sethu S, Jeyabalan N, Ghosh A. Trehalose augments autophagy to mitigate stress induced inflammation in human corneal cells. The ocular surface. 2019 Aug 11. PMID: 314122903


Gopinath C, Chodisetty S, Ghosh A, Nelson EJ. Efficiency of different fragment lengths of the ubiquitous chromatin opening element HNRPA2B1-CBX3 in driving human CD18 gene expression within self-inactivating lentiviral vectors for gene therapy applications. Gene. 2019 Jun 11. PMID: 31200085


Ghosh A, Nishtala K. Biofluid lipidome: a source for potential diagnostic biomarkers. Clinical and translational medicine. 2017 Dec;6(1):22. PMID: 28639235


Pahuja NK, Shetty R, Deshmukh R, Sharma A, Nuijts RMMA, Jhanji V, Sethu S, Ghosh A. In vivo confocal microscopy and tear cytokine analysis in post-LASIK ectasia. Br J Ophthalmol. 2017 Apr 27. PMID: 28450380


Shetty R, Sureka S, Kusumgar P, Sethu S, Sainani K. Allergen-specific exposure associated with high immunoglobulin E and eye rubbing predisposes to progression of keratoconus. Indian J Ophthalmol. 2017 May;65(5):399-402. PMID: 28573997


Shetty R, Sharma A, Pahuja N, Chevour P, Padmajan N, Dhamodaran K, Jayadev C, M M A Nuijts R, Ghosh A, Nallathambi J. Oxidative stress induces dysregulated autophagy in corneal epithelium of keratoconus patients. PLoS One. 2017 Sep 13;12(9):e0184628. PMID: 28902914


Subramani M, Ponnalagu M, Krishna L, Jeyabalan N, Chevour P, Sharma A, Jayadev C, Shetty R, Begum N, Archunan G, Das D. Resveratrol reverses the adverse effects of bevacizumab on cultured ARPE-19 cells. Sci Rep. 2017 Sep 25;7(1):12242. PMID: 28947815


Anegondi N, Chidambara L, Bhanushali D, Gadde SGK, Yadav NK, Sinha Roy A. An automated framework to quantify areas of regional ischemia in retinal vascular diseases with OCT angiography. J Biophotonics. 2017 Jul 12. PMID: 28700136


Chandapura RS, Shetty R, Shroff R, Shilpy N, Francis M, Sinha Roy A. OCT layered tomography of the cornea provides new insights on remodeling after photorefractive keratectomy. J Biophotonics. 2017 Jul 12. PMID: 28700139


Matalia J, Francis M, Gogri P, Panmand P, Matalia H, Sinha Roy A. Correlation of Corneal Biomechanical Stiffness With Refractive Error and Ocular Biometry in a Pediatric Population. Cornea. 2017 Oct;36(10):1221-1226. PMID: 28731878


Shetty R, Pahuja N, Roshan T, Deshmukh R, Francis M, Ghosh A, Sinha Roy A. Customized Corneal Cross-linking Using Different UVA Beam Profiles. J Refract Surg. 2017 Oct 1;33(10):676-682. PMID: 28991335


Aung T, et al. Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci.
Nat Genet. 2017 Jul;49(7):993-1004. PMID: 28553957


Mahendradas P, Madhu S, Kawali A, Sinha Roy A, Vala R, Vinekar A, Shetty R.Enhanced Vitreous Imaging in Uveitis. Ocul Immunol Inflamm. 2017 Oct 16:1-7. PMID: 29035612


Krishna L, Dhamodaran K, Jayadev C, Chatterjee K, Shetty R, Khora SS, Das D. Nanostructured scaffold as a determinant of stem cell fate. Stem Cell Res Ther. 2016 Dec 30;7(1):188. doi: 10.1186/s13287-016-0440-y. Review. PubMed PMID: 28038681; PubMed Central PMCID: PMC5203716.


Shetty R, Sethu S, Chevour P, Deshpande K, Pahuja N, Nagaraja H, Pindipapanahalli N, Ghosh A. Lower Vitamin D Level and Distinct Tear Cytokine Profile Were Observed in Patients with Mild Dry Eye Signs but Exaggerated Symptoms. Transl Vis Sci Technol. 2016 Dec 14;5(6):16. PubMed PMID: 27980879; PubMed Central PMCID: PMC5156440.


Balne PK, Agrawal R, Au VB, Lee B, Loo E, Tong L, Ghosh A, Teoh SC, Connolly J, Tan P. Dataset of tear film cytokine levels in dry eye disease (DED) patients with and without HIV infection. Data Brief. 2016 Nov 26;10:14-16. PubMed PMID: 27942559; PubMed Central PMCID: PMC5137335.


Hutter G, Sailer M, Azad TD, von Bueren AO, Nollau P, Frank S, Tostado C, Sarvepalli D, Ghosh A, Ritz MF, Boulay JL, Mariani L. Reverse phase protein arrays enable glioblastoma molecular subtyping. J Neurooncol. 2016 Nov 17. [Epub ahead of print] PubMed PMID: 27858266.


Kumar RS, Anegondi N, Chandapura RS, Sudhakaran S, Kadambi SV, Rao HL, Aung T, Sinha Roy A. Discriminant Function of Optical Coherence Tomography Angiography to Determine Disease Severity in Glaucoma. Invest Ophthalmol Vis Sci. 2016 Nov 1;57(14):6079-6088. doi: 10.1167/iovs.16-19984. PubMed PMID: 27820876.


Shroff R, Francis M, Pahuja N, Veeboy L, Shetty R, Sinha Roy A. Quantitative Evaluation of Microdistortions in Bowman's Layer and Corneal Deformation after Small Incision Lenticule Extraction. Transl Vis Sci Technol. 2016 Oct 17;5(5):12. PubMed PMID: 27777827; PubMed Central PMCID: PMC5072544.


Pahuja NK, Shetty R, Sinha Roy A, Thakkar MM, Jayadev C, Nuijts RM, Nagaraja H. Laser Vision Correction with Q Factor Modification for Keratoconus Management. Curr Eye Res. 2016 Oct 21:1-7. [Epub ahead of print] PubMed PMID: 27767357.


Pahuja N, Kumar NR, Shroff R, Shetty R, Nuijts RM, Ghosh A, Sinha-Roy A, Chaurasia SS, Mohan RR, Ghosh A. Differential Molecular Expression of Extracellular Matrix and Inflammatory Genes at the Corneal Cone Apex Drives Focal Weakening in Keratoconus. Invest Ophthalmol Vis Sci. 2016 Oct 1;57(13):5372-5382. doi: 10.1167/iovs.16-19677. PubMed PMID: 27732724.


Sethu S, Shetty R, Deshpande K, Pahuja N, Chinnappaiah N, Agarwal A, Sharma A, Ghosh A. Correlation between tear fluid and serum vitamin D levels. Eye Vis (Lond). 2016 Sep 2;3(1):22. doi: 10.1186/s40662-016-0053-7. PubMed PMID: 27595117; PubMed Central PMCID: PMC5009644.


Agrawal R, Balne PK, Veerappan A, Au VB, Lee B, Loo E, Ghosh A, Tong L, Teoh SC, Connolly J, Tan P. A distinct cytokines profile in tear film of dry eye disease (DED) patients with HIV infection. Cytokine. 2016 Dec;88:77-84. doi: 10.1016/j.cyto.2016.08.026. PubMed PMID: 27585367.


Sailer MH, Sarvepalli D, Brégère C, Fisch U, Guentchev M, Weller M, Guzman R, Bettler B, Ghosh A, Hutter G. An Enzyme- and Serum-free Neural Stem Cell Culture  Model for EMT Investigation Suited for Drug Discovery. J Vis Exp. 2016 Aug 23;(114). doi: 10.3791/54018. PubMed PMID: 27583933.


Pahuja N, Shroff R, Pahanpate P, Francis M, Veeboy L, Shetty R, Nuijts RM, Roy AS. Application of high resolution OCT to evaluate irregularity of Bowman's layer in asymmetric keratoconus. J Biophotonics. 2016 Aug 24. doi: 10.1002/jbio.201600106. [Epub ahead of print] PubMed PMID: 27555452.


Nishtala K, Pahuja N, Shetty R, Nuijts RM, Ghosh A. Tear biomarkers for keratoconus. Eye Vis (Lond). 2016 Aug 4;3:19. doi: 10.1186/s40662-016-0051-9. Review. PubMed PMID: 27493978; PubMed Central PMCID: PMC4973115.


Kumaramanickavel G. Age-Related Macular Degeneration: Genetics and Biology. Asia Pac J Ophthalmol (Phila). 2016 Jul-Aug;5(4):229-35. doi:10.1097/APO.0000000000000223. PubMed PMID: 27488064.


Bhanushali D, Anegondi N, Gadde SG, Srinivasan P, Chidambara L, Yadav NK, Sinha Roy A. Linking Retinal Microvasculature Features With Severity of Diabetic Retinopathy Using Optical Coherence Tomography Angiography. Invest Ophthalmol Vis Sci. 2016 Jul 1;57(9):OCT519-25. doi: 10.1167/iovs.15-18901. PubMed PMID: 27472275.


Kulsum S, Sudheendra HV, Pandian R, Ravindra DR, Siddappa G, R N, Chevour P, Ramachandran B, Sagar M, Jayaprakash A, Mehta A, Kekatpure V, Hedne N, Kuriakose MA, Suresh A. Cancer stem cell mediated acquired chemoresistance in head and neck cancer can be abrogated by aldehyde dehydrogenase 1 A1 inhibition. Mol Carcinog. 2017 Feb;56(2):694-711. doi: 10.1002/mc.22526. PubMed PMID: 27380877.


Pahuja N, Kumar NR, Francis M, Shanbagh S, Shetty R, Ghosh A, Sinha Roy A. Correlation of Clinical and Biomechanical Outcomes of Accelerated Crosslinking (9 mW/cm(2) in 10 minutes) in Keratoconus with Molecular Expression of Ectasia-Related Genes. Curr Eye Res. 2016 Nov;41(11):1419-1423. PubMed PMID: 27159267.


Kemmanu V, Hegde K, Giliyar SK, Shetty BK, Kumaramanickavel G, McCarty CA. Prevalence of Childhood Blindness and Ocular Morbidity in a Rural Pediatric Population in Southern India: The Pavagada Pediatric Eye Disease Study-1. Ophthalmic Epidemiol. 2016 Jun;23(3):185-92. doi: 10.3109/09286586.2015.1090003.  PubMed PMID: 27142419.


Gadde SG, Anegondi N, Bhanushali D, Chidambar L, Yadav NK, Khurana A, Roy AS. Author Response: Quantification of Vessel Density in Retinal Optical Coherence Tomography Angiography Images Using Local Fractal Dimension. Invest Ophthalmol Vis Sci. 2016 Apr 1;57(4):2263. doi: 10.1167/iovs.16-19368. PubMed PMID: 27124321.


Ghosh A, Shetty R, Chaurasia SS. Author Response: Causal Management of Keratoconus: Controlling Inflammation. Invest Ophthalmol Vis Sci. 2016 Apr 1;57(4):2165. doi: 10.1167/iovs.16-19532. PubMed PMID: 27111564.


Khor CC, Do T, Jia H, Nakano M, George R, Abu-Amero K, Duvesh R, Chen LJ, Li Z, Nongpiur ME, Perera SA, Qiao C, Wong HT, Sakai H, Barbosa de Melo M, Lee MC, Chan AS, Azhany Y, Dao TL, Ikeda Y, Perez-Grossmann RA, Zarnowski T, Day AC, Jonas JB, Tam PO, Tran TA, Ayub H, Akhtar F, Micheal S, Chew PT, Aljasim LA, Dada T, Luu TT, Awadalla MS, Kitnarong N, Wanichwecharungruang B, Aung YY, Mohamed-Noor J, Vijayan S, Sarangapani S, Husain R, Jap A, Baskaran M, Goh D, Su DH, Wang H, Yong VK, Yip LW, Trinh TB, Makornwattana M, Nguyen TT, Leuenberger EU, Park KH, Wiyogo WA, Kumar RS, Tello C, Kurimoto Y, Thapa SS, Pathanapitoon K, Salmon JF, Sohn YH, Fea A, Ozaki M, Lai JS, Tantisevi V, Khaing CC, Mizoguchi T,  Nakano S, Kim CY, Tang G, Fan S, Wu R, Meng H, Nguyen TT, Tran TD, Ueno M, Martinez JM, Ramli N, Aung YM, Reyes RD, Vernon SA, Fang SK, Xie Z, Chen XY, Foo  JN, Sim KS, Wong TT, Quek DT, Venkatesh R, Kavitha S, Krishna Das SR, Soumittra N, Shantha B, Lim BA, Ogle J, de Vasconcellos JP, Costa VP, Abe RY, de Souza BB, Sng CC, Aquino MC, Kosior-Jarecka E, Fong GB, Tamanaja VC, Fujita R, Jiang Y, Waseem  N, Low S, Pham HN, Al-Shahwan S, Craven ER, Khan MI, Dada R, Mohanty K, Faiq MA, Hewitt AW, Burdon KP, Gan EH, Prutthipongsit A, Patthanathamrongkasem T, Catacutan MA, Felarca IR, Liao CS, Rusmayani E, Istiantoro VW, Consolandi G, Pignata G, Lavia C, Rojanapongpun P, Mangkornkanokpong L, Chansangpetch S, Chan JC, Choy BN, Shum JW, Than HM, Oo KT, Han AT, Yong VH, Ng XY, Goh SR, Chong YF, Hibberd ML, Seielstad M, Png E, Dunstan SJ, Chau NV, Bei J, Zeng YX, Karkey A, Basnyat B, Pasutto F, Paoli D, Frezzotti P, Wang JJ, Mitchell P, Fingert JH, Allingham RR, Hauser MA, Lim ST, Chew SH, Ebstein RP, Sakuntabhai A, Park KH, Ahn J, Boland G, Snippe H, Stead R, Quino R, Zaw SN, Lukasik U, Shetty R, Zahari M, Bae HW, Oo NL, Kubota T, Manassakorn A, Ho WL, Dallorto L, Hwang YH, Kiire CA, Kuroda M, Djamal ZE, Peregrino JI, Ghosh A, Jeoung JW, Hoan TS, Srisamran N, Sandragasu T, Set SH, Doan VH, Bhattacharya SS, Ho CL, Tan DT, Sihota R, Loon SC, Mori K, Kinoshita S, Hollander AI, Qamar R, Wang YX, Teo YY, Tai ES, Hartleben-Matkin C, Lozano-Giral D, Saw SM, Cheng CY, Zenteno JC, Pang CP, Bui HT, Hee O, Craig JE, Edward DP, Yonahara M, Neto JM, Guevara-Fujita ML, Xu L, Ritch R, Liza-Sharmini AT, Wong TY, Al-Obeidan S, Do NH, Sundaresan P, Tham CC, Foster PJ, Vijaya L, Tashiro K, Vithana EN, Wang N, Aung T. Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma. Nat Genet. 2016 May;48(5):556-62. doi: 10.1038/ng.3540. PubMed PMID: 27064256.


Shetty R, Shroff R, Kaweri L, Jayadev C, Kummelil MK, Sinha Roy A. Intra-Operative Cap Repositioning in Small Incision Lenticule Extraction (SMILE)  for Enhanced Visual Recovery. Curr Eye Res. 2016 Dec;41(12):1532-1538. PubMed PMID: 27044473.


Subramani M, Murugeswari P, Dhamodaran K, Chevour P, Gunasekaran S, Kumar RS, Jayadev C, Shetty R, Begum N, Das D. Short Pulse of Clinical Concentration of Bevacizumab Modulates Human Retinal Pigment Epithelial Functionality. Invest Ophthalmol Vis Sci. 2016 Mar;57(3):1140-52. doi: 10.1167/iovs.15-18330. PubMed PMID: 26975025.


Dhamodaran K, Subramani M, Matalia H, Jayadev C, Shetty R, Das D. One for all: A standardized protocol for ex vivo culture of limbal, conjunctival and oral mucosal epithelial cells into corneal lineage. Cytotherapy. 2016 Apr;18(4):546-61. doi: 10.1016/j.jcyt.2016.01.003. PubMed PMID: 26971683.


Tejwani S, Devi S, Dinakaran S, Shetty R, Meshram P, Francis M, Sinha Roy A. Diagnostic Efficacy of Normalization of Corneal Deformation Variables by the Intraocular Pressure in Glaucomatous Eyes. Invest Ophthalmol Vis Sci. 2016 Mar;57(3):1082-6. doi: 10.1167/iovs.15-18569. PubMed PMID: 26968738.


Jeyabalan N, Clement JP. SYNGAP1: Mind the Gap. Front Cell Neurosci. 2016 Feb 15;10:32. doi: 10.3389/fncel.2016.00032. Review. PubMed PMID: 26912996; PubMed Central PMCID: PMC4753466.


Pahuja NK, Shetty R, Nuijts RM, Agrawal A, Ghosh A, Jayadev C, Nagaraja H. An In Vivo Confocal Microscopic Study of Corneal Nerve Morphology in Unilateral Keratoconus. Biomed Res Int. 2016;2016:5067853. doi: 10.1155/2016/5067853. PubMed PMID: 26904679; PubMed Central PMCID: PMC4745354.


Shetty R, Sethu S, Deshmukh R, Deshpande K, Ghosh A, Agrawal A, Shroff R. Corneal Dendritic Cell Density Is Associated with Subbasal Nerve Plexus Features, Ocular Surface Disease Index, and Serum Vitamin D in Evaporative Dry Eye Disease. Biomed Res Int. 2016;2016:4369750. doi: 10.1155/2016/4369750. PubMed PMID: 26904676; PubMed Central PMCID: PMC4745572.


Dennis C, Sethu S, Nayak S, Mohan L, Morsi YY, Manivasagam G. Suture materials - Current and emerging trends. J Biomed Mater Res A. 2016 Jun;104(6):1544-59. doi: 10.1002/jbm.a.35683. Review. PubMed PMID: 26860644.


Gadde SG, Anegondi N, Bhanushali D, Chidambara L, Yadav NK, Khurana A, Sinha Roy A. Quantification of Vessel Density in Retinal Optical Coherence Tomography Angiography Images Using Local Fractal Dimension. Invest Ophthalmol Vis Sci. 2016  Jan 1;57(1):246-52. doi: 10.1167/iovs.15-18287. PubMed PMID: 26803800.


Tejwani S, Dinakaran S, Joshi A, Shetty R, Sinha Roy A. A cross-sectional study to compare intraocular pressure measurement by sequential use of Goldman applanation tonometry, dynamic contour tonometry, ocular response analyzer, and Corvis ST. Indian J Ophthalmol. 2015 Nov;63(11):815-20. doi: 10.4103/0301-4738.171956. PubMed PMID: 26669331; PubMed Central PMCID: PMC4730691.


Dhamodaran K, Subramani M, Jeyabalan N, Ponnalagu M, Chevour P, Shetty R, Matalia H, Shetty R, Prince SE, Das D. Characterization of ex vivo cultured limbal, conjunctival, and oral mucosal cells: A comparative study with implications in transplantation medicine. Mol Vis. 2015 Jul 31;21:828-45. PubMed  PMID: 26283864; PubMed Central PMCID: PMC4522244.


Shetty R, Deshpande K, Ghosh A, Sethu S. Management of Ocular Neuropathic Pain With Vitamin B12 Supplements: A Case Report. Cornea. 2015 Oct;34(10):1324-5. doi: 10.1097/ICO.0000000000000572. PubMed PMID: 26266431.


Ma L, Li Z, Liu K, Rong SS, Brelen ME, Young AL, Kumaramanickavel G, Pang CP, Chen H, Chen LJ. Association of Genetic Variants with Polypoidal Choroidal Vasculopathy: A Systematic Review and Updated Meta-analysis. Ophthalmology. 2015  Sep;122(9):1854-65. doi: 10.1016/j.ophtha.2015.05.012. Review. PubMed PMID: 26081444.


Gopinath C, Nathar TJ, Ghosh A, Hickstein DD, Remington Nelson EJ. Contemporary Animal Models For Human Gene Therapy Applications. Curr Gene Ther. 2015;15(6):531-40. Review. PubMed PMID: 26415576.


Shetty R, Matalia H, Srivatsa P, Ghosh A, Dupps WJ Jr, Sinha Roy A. A novel zernike application to differentiate between three-dimensional corneal thickness  of normal corneas and corneas with keratoconus. Am J Ophthalmol. 2015 Sep;160(3):453-462.e2. doi: 10.1016/j.ajo.2015.06.001. PubMed PMID: 26067190.


Shetty R, Kaweri L, Pahuja N, Deshpande K, Thakkar M, Sinha Roy A. Association Between Corneal Deformation and Ease of Lenticule Separation From Residual Stroma in Small Incision Lenticule Extraction. Cornea. 2015 Sep;34(9):1067-71. doi: 10.1097/ICO.0000000000000463. PubMed PMID: 26020826.


Shetty R, Nuijts RM, Nanaiah SG, Anandula VR, Ghosh A, Jayadev C, Pahuja N, Kumaramanickavel G, Nallathambi J. Two novel missense substitutions in the VSX1 gene: clinical and genetic analysis of families with Keratoconus from India. BMC  Med Genet. 2015 May 12;16:33. doi: 10.1186/s12881-015-0178-x. PubMed PMID: 25963163; PubMed Central PMCID: PMC4630895.


Govindan SV, Kulsum S, Pandian RS, Das D, Seshadri M, Hicks W Jr, Kuriakose MA, Suresh A. Establishment and characterization of triple drug resistant head and neck squamous cell carcinoma cell lines. Mol Med Rep. 2015 Aug;12(2):3025-32. doi: 10.3892/mmr.2015.3768. PubMed PMID: 25962396.


Sinha Roy A, Kurian M, Matalia H, Shetty R. Air-puff associated quantification of non-linear biomechanical properties of the human cornea in vivo. J Mech Behav Biomed Mater. 2015 Aug;48:173-82. doi: 10.1016/j.jmbbm.2015.04.010. PubMed PMID: 25955559.


Shetty R, Nuijts RM, Srivatsa P, Jayadev C, Pahuja N, Akkali MC, Sinha Roy A. Understanding the Correlation between Tomographic and Biomechanical Severity of Keratoconic Corneas. Biomed Res Int. 2015;2015:294197. doi: 10.1155/2015/294197. PubMed PMID: 25945330; PubMed Central PMCID: PMC4402575.


Battu R, Verma A, Hariharan R, Krishna S, Kiran R, Jacob J, Ganapathy A, Ramprasad VL, Kumaramanickavel G, Jeyabalan N, Ghosh A. Identification of Novel Mutations in ABCA4 Gene: Clinical and Genetic Analysis of Indian Patients with Stargardt Disease. Biomed Res Int. 2015;2015:940864. doi: 10.1155/2015/940864. PubMed PMID: 25922843; PubMed Central PMCID: PMC4398921.


Simple M, Suresh A, Das D, Kuriakose MA. Cancer stem cells and field cancerization of oral squamous cell carcinoma. Oral Oncol. 2015 Jul;51(7):643-51. doi: 10.1016/j.oraloncology.2015.04.006. Review. PubMed PMID: 25920765.